Diesel exhaust fumes change the blood of women more than men

WINNIPEG, Manitoba – A new study shows that air pollution affects women more than men. Researchers say diesel exhaust fumes alter components of the blood affected by inflammation and infection — but these changes were greater among women.

Scientists at the University of Manitoba say that levels of 90 proteins in the body were significantly different in men and women after exposure to vapors. Some of these proteins are known to play a role in inflammation, damage repair and blood clotting. heart disease and the immune system. The differences became more pronounced when the volunteers were exposed to higher levels of diesel exhaust.

Previous research found gender differences in How does air pollution affect Lung diseases such as asthma and respiratory infections.

In this latest study, the Canadian team recruited five men and five women, who were all Healthy non-smokers. Each spent hours breathing air and filtered air containing diesel exhaust fumes at three different concentrations: 20, 50 and 150 micrograms of fine particles per cubic meter. Participants were given a one hour break between each presentation.

Volunteers donated blood samples 24 hours after each exposure, and the researchers performed detailed examinations of the volunteers’ blood plasma. Plasma is the liquid component of blood that carries blood cells, as well as hundreds of other proteins and molecules throughout the body. Using a well-established analysis technique called liquid chromatography-mass spectrometryThe team looked for changes in levels of various proteins after exposure to diesel exhaust and compared the changes in females and males.

“These are preliminary results, but they show that exposure to diesel exhaust has different effects on female bodies compared to males, and this may indicate that air pollution More dangerous for females Study co-author Nilufer Mukherjee, from the University of Manitoba in Canada, says in a statement statement. This is important because respiratory diseases such as asthma are known to affect females and males differently, with females being more likely to develop severe asthma that does not respond to treatments. Therefore, we need to learn more about how females and males respond to air pollution and what that means for the prevention, diagnosis and treatment of respiratory diseases.”

the findings Presented at the 2022 International Congress of the European Respiratory Society (ERS) in Barcelona, ​​Spain.

Zorana Andersen, from the University of Copenhagen in Denmark, is chair of the ERS Environment and Health Committee. She was not involved in the study, but notes that the work reveals valuable insights into how diesel exhaust affects men and women differently. “We know that exposure to air pollution, especially diesel exhaust, is a major risk factor for diseases such as asthma and COPD,” she says. “There is very little we can do as individuals avoid breathing polluted air, So we need governments to set and enforce limits on air pollutants. We also need to understand how and why air pollution contributes to ill health.”

Reporting by Southwest News Service writer Gwen Wright.